A modification of the jump-flinch technique for measuring pain sensitivity in rats☆
References (17)
Sex-dependent and sex-independent neural control of reactivity to electric footshock in the rat
Expl Neurol.
(1972)- et al.
Alterations in pain thresholds and avoidance conditioning in rats with septal lesions
Neuropsychologia
(1971) - et al.
Brain 5-hydroxytriptamine correlates of behavior in rats: strain and sex variability
Physiol. Behav.
(1972) - et al.
Observations on the neuropharmacology of morphine and morphinelike analgesia
Archs int. Pharmacodyn Thér.
(1960) Analysis and measurement of pain in animals: a new conception in pain
- et al.
A method for determining loss of pain sensation
J. Pharmac. exp. Ther.
(1941) A new technique for the investigation of some analgesic drugs on a reflexive behavior in the rat
Psychopharmacologia
(1961)- et al.
Strain differences in the analgesic response to morphine as measured on the hot plate
Archs int. Pharmacodyn Thér.
(1973)
Cited by (47)
Use of von Frey filaments to assess nociceptive sensitization in the hornworm, Manduca sexta
2016, Journal of Neuroscience MethodsCitation Excerpt :In models such as rats, defensive behaviors are monitored by a number of different assays. For instance, the tail flick, hind paw withdrawal and jump-flinch are all responses to noxious stimuli that may be sensitized after formalin injection, high-intensity light beams, hot plates or after spinal nerve ligation surgery (e.g., Juszkiewicz-Donsbach and Levy, 1962; Bonnet and Peterson, 1975; Pitcher et al., 1999; Kim et al., 2014; reviewed by Bannon, 2001; Bannon and Malmberg, 2007; Gregory et al., 2013). These responses are quantified by assessing either the latency to respond to the noxious stimulus or the intensity of the stimulus causing a response (the threshold response).
Nociceptive threshold and analgesic response to morphine in aged and young adult rats as determined by thermal radiation and intracerebral electrical stimulation
2006, Pharmacology Biochemistry and BehaviorGait analysis as an objective measure in a chronic pain model
2002, Journal of Neuroscience MethodsAutomated analysis of foot-shock sensitivity and concurrent freezing behavior in mice
2002, Journal of Neuroscience MethodsEffects of inhalation of cadmium on the rat olfactory system: Behavior and morphology
1996, Neurotoxicology and TeratologyA revised rotarod procedure for measuring the effect of antinociceptive drugs on motor function in the rat
1991, Journal of Pharmacological Methods
- ☆
This work was supported in part by grant number 1R01-DA-00356-01 awarded to the senior author by NIMH.
- 2
Present address: Department of Psychiatry, New York University School of Medicine, New York, N.Y. 10016.