Reproductive state modulates ethanol intake in rats: Effects of ovariectomy, ethanol concentration, estrous cycle and pregnancy
References (24)
The effects of corticosteroids and ACTH on sensory systems
Prog. Brain Res.
(1970)Experimentally induced changes in the free selection of ethanol
Int. Rev. Neurobiol.
(1960)- et al.
Decreased ethanol consumption as a function of pregnancy and lactation in C57BL mice
Pharmac. Biochem. Behav.
(1980) Saccharin aversion in the rat following adrenalectomy
Physiol. Behav.
(1977)Sex hormones, regulatory behaviors and body weight
Adv. Stud. Behav.
(1976)- et al.
Taste preference of female rats: Modification by neonatal hormones, food deprivation and prior experience
Physiol. Behav.
(1969) - et al.
Hormonal modulation of responsiveness to an aversive taste stimulus in rats
Physiol. Behav.
(1970) Hormonal determinants of the sex differences in saccharin preference, food intake and body weight
Physiol. Behav.
(1969)Relation entre l'effect inhibiteur des oestrogenes sur la consommation d'alcool du rat et leur action genitale
Archs Sci. physiol.
(1960)- et al.
Effects of pregnancy and lactation on voluntary alcohol intake of hamsters
Changes in ethanol consumption by pregnant pigtailed macaques
J. Stud. Alcohol
Species variation in preference for alcohol and in effects of diet or drugs on this preference
J. Pharmac. exp. Ther.
Cited by (43)
Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder
2022, Biological PsychiatryOperant, oral alcohol self-administration: Sex differences in Sardinian alcohol-preferring rats
2019, AlcoholCitation Excerpt :The pattern of daily alcohol drinking over the 10-day free choice period of ovariectomized sP rats was virtually superimposable to that of male sP rats, confirming that ovariectomy may “defeminize” multiple drug-related behavioral responses, including alcohol drinking (see Becker & Koob, 2016). Mean daily alcohol drinking was steadily lower in ovariectomized than intact female sP rats, extending to female sP rats previous data on depletion of circulating ovarian hormones reducing alcohol drinking in rats (Forger & Morin, 1982; Torres, Walker, Beas, & O'Dell, 2014; however, see also; Almeida et al., 1998; Cailhol & Mormède, 2001; Ford, Eldridge, & Samson, 2002; for review, see; Becker & Koob, 2016; Hilderbrand & Lasek, 2018). In agreement with these literature data, chronic replacement treatment with estradiol dose-dependently increased alcohol intake in ovariectomized female Long-Evans rats exposed to the 2-bottle “alcohol vs. water” choice regimen (Ford, Eldridge, & Samson, 2004; Ford et al., 2002).
Gonadal hormones affect alcohol drinking, but not cue + yohimbine-induced alcohol seeking, in male and female rats
2019, Physiology and BehaviorCitation Excerpt :Postpubertal gonadectomy, which seeks to eliminate the activational effects of gonadal hormones, has been shown to slightly reduce [33], increase [31,32], or have no effect [54] on drinking in males; these same studies showed either slight trends (though confounded by several factors) for reductions in [33,54] or no effect [31] of drinking in females. Still other studies in females have shown OVX to significantly reduce ethanol intake [27,29,55,56]. Similar findings are evident when animals are gonadectomized prepubertally, with increased drinking in CAST males [31,32,57], and either decreased [57] or unaffected [31] drinking in OVX females, indicating that prepubertal organizational effects of hormones are likely responsible for these outcomes.
- 1
Submitted as part of an Honors Thesis in Psychology, Dartmouth College, Hanover, NH.