Modifications in adrenal hormones response to ethanol by prior ethanol dependence

https://doi.org/10.1016/0091-3057(85)90031-0Get rights and content

Abstract

Ethanol was administered to rats by means of a liquid diet for 16 days; after an ethanol-free interval of four weeks, animals received a test (IP) dose of ethanol (2 g/kg), and the adrenocortical and adrenomedullary responses were evaluated. Chronically ethanol-exposed animals showed tolerance to the stimulatory effect of ethanol in the pituitary-adrenal axis. Likewise, previously dependent rats showed tolerance to the increase in the activity of the adrenomedullary function induced by acute administration of the drug. Our results indicate that chronic ethanol ingestion can induce persistent changes after complete alcohol abstinence.

References (27)

  • G. Freund

    Physical dependence on ethanol: Methodological considerations

  • S.E. Gitlow et al.

    Persistence of abnormal REM sleep response to ethanol as a result of previous ethanol ingestion

    Psychopharmacologia

    (1973)
  • S.R. Goldberg et al.

    Nalorphine increased sensitivity of monkeys formerly dependent on morphine

    Science

    (1969)
  • Cited by (6)

    View full text