Brief communicationMethysergide potentiates the hyperactivity produced by MDMA in rats☆
References (26)
- et al.
Self-administration of methylenedioxymethamphetamine (MDMA) by Rhesus monkeys
Drug Alcohol Depend
(1986) - et al.
Discriminative stimulus properties of (±)-3,4-methylenedioxymethamphetamine and (±)-3,4-methylenedioxyamphetamine in pigeons
Drug Alcohol Depend
(1986) - et al.
Evidence for specific methylenedioxymethamphetamine (ectasy) binding sites in the rat brain
Eur J Pharmacol
(1985) - et al.
Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways
Brain Res
(1976) - et al.
The effects of (±)-3,4-methylenedioxyamphetamine and (±)-3,4-methylenedioxyamphetamine in monkeys trained to discriminate (+)-amphetamine from saline
Drug Alcohol Depend
(1986) - et al.
Absence of serotonergic influence on apomorphine-induced stereotypy
Eur J Pharmacol
(1972) Discriminative profile of MDMA
Pharmacol Biochem Behav
(1986)- et al.
The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain
Eur J Pharmacol
(1986) Getting high on ‘Ecstacy’
Newsweek
(1985)- et al.
Absolute configuration and psychomimetic activity
NIDA Res Monogr
(1978)
Histamine and 5-hydroxytryptamine (Serotonin) and their antagonists
An observational method for quantifying the behavioural effects of dopamine agonists: Contrasting effects of d-amphetamine and apomorphine
Psychopharmacology (Berlin)
Motor effects of serotonin in the central nervous system
Life Sci
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Contrasting effects of d-methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in rats
2012, Drug and Alcohol DependenceCitation Excerpt :Moreover, there is a parallel in the locomotor stimulant effects of MDMA. Prior reports have found that low to moderate doses of MDMA increase horizontal ambulation (Bankson and Cunningham, 2002; Bubar et al., 2004; Gold and Koob, 1988; Gold et al., 1988; Herin et al., 2005) yet we have shown previously that wheel activity is suppressed by 5 mg/kg MDMA (Gilpin et al., 2011). Interestingly, MDMA suppresses spontaneous activity in nonhuman primates (Crean et al., 2007; Fantegrossi et al., 2009; Von Huben et al., 2007).
Influences of activity wheel access on the body temperature response to MDMA and methamphetamine
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :The role sustained motor activity plays in modulating the body temperature response of experimental animals remains nearly uninvestigated, despite prior work suggesting that increased muscle thermogenesis is an important contributor to MDMA-induced hyperthermia (Mills et al., 2004; Sprague et al., 2005). Despite the fact that MDMA has been shown repeatedly to increase open field locomotor behavior in rats at doses of about 10 mg/kg of either the racemic mixture or the S(+) stereoisomer (Bankson and Cunningham, 2002; Gold and Koob, 1988, 1989; Walker et al., 2007), the role of locomotor activity has not been explicitly manipulated in thermoregulatory studies. MDMA does not appear to be a locomotor or behavioral stimulant in macaque monkeys (Crean et al., 2007; 2006; Fantegrossi et al., 2009; Taffe et al., 2006), thus the rat is a preferred model for this purpose.
Oral administration of (±)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques
2007, Pharmacology Biochemistry and BehaviorA developmental comparison of the neurobehavioral effects of ecstasy (MDMA)
2007, Neurotoxicology and TeratologyCitation Excerpt :This sexual response could be occurring because MDMA appears to activate norepinephrine receptors in the vas deferens [79,126] although central factors are also likely to be involved. MDMA, like other amphetamines, increases locomotion in adults [50,55]. Amphetamine induced hyperactivity in mice emerges at weanling [80].
Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys
2006, Drug and Alcohol DependenceSerotonin (1A) receptor involvement in acute 3,4- methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat
2005, Progress in Neuro-Psychopharmacology and Biological Psychiatry
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This is publication number 4948BCR from the Research Institute of Scripps Clinic, La Jolla.