The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

doi:10.1016/0091-3057(90)90385-U

Pharmacology Biochemistry and Behavior

Volume 35, Issue 4, April 1990, Pages 955-962

https://doi.org/10.1016/0091-3057(90)90385-U Get rights and content

Abstract

The selective 5-HT₃ receptor antagonist, ondansetron, has been assessed in three tests of cognition in the mouse, rat and marmoset. In a habituation test in the mouse, ondansetron facilitated performance in young adult and aged animals, and inhibited an impairment in habituation induced by scopolamine, electrolesions or ibotenic acid lesions of the nucleus basalis magnocellularis. Arecoline failed to improve basal performance in young adult mice but inhibited the impairment caused by scopolamine and lesions of the nucleus basalis magnocellularis. In the T-maze reinforced alternation task in rats, ondansetron and arecoline antagonised a scopolamine-induced impairment. In an object discrimination and reversal learning task in the marmoset, assessed using a Wisconsin General Test Apparatus, ondansetron improved performance in a reversal learning task. We conclude that ondansetron potently improves basal performance in rodent and primate tests of cognition and inhibits the impairments in performance caused by cholinergic deficits.

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The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

Abstract

Behav. Brain Res.

Pharmacol. Biochem. Behav.

Neuropharmacology

Pharmacol. Biochem. Behav.

Trends Pharmacol. Sci.

Brain Res.

J. Neurosci.

Neuropsychologia

Brain Res.

Neuropsychologia

Life Sci.

Brain Res.

Brain Res.

Eur. J. Pharmacol.

Physiol. Behav.

Behav. Brain Res.

Brain Res.

Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice

Psychopharmacology (Berlin)

Discrimination learning and reversal following electrolytic median raphe lesions

Soc. Neurosci. Abstr.

Pharmacological investigations on neurotransmitter involvement in passive avoidance responding: A review and some new results

Neurosci. Biobehav. Rev.

5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue

Nature

[3H]zacopride: ligand for the identification of 5-HT3 recognition sites

J. Pharm. Pharmacol.

The cholinergic hypothesis of geriatric memory dysfunction

Science

The effects of ondansetron, a 5-HT₃ receptor antagonist, on cognition in rodents and primates

5-HT₃ receptors mediate inhibition of acetylcholine release in cortical tissue

[³H]zacopride: ligand for the identification of 5-HT₃ recognition sites