Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat☆,☆☆
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Drinking to death: Hyponatraemia induced by synthetic phenethylamines
2020, Drug and Alcohol DependenceHigh ambient temperature increases the toxicity and lethality of 3,4-methylenedioxymethamphetamine and methcathinone
2020, Pharmacology Biochemistry and BehaviorMinocycline attenuates 3,4-methylenedioxymethamphetamine-induced hyperthermia in the rat brain
2019, European Journal of PharmacologyCitation Excerpt :These varying temperature responses under differing environmental conditions are consistent with those described previously (Daws et al., 2000; Malberg and Seiden, 1998; Brown and Kiyatkin, 2004; Gordon et al., 1991). Acute MDMA administration produces a significant release of 5-HT and DA in the brain, both of which have been linked to the development of hyperthermia (Stone et al., 1986; Malberg and Seiden, 1998; Colado et al., 1999; Sabol and Seiden, 1998; Gordon et al., 1991; Stanley et al., 2007). This monoamine release post drug administration has been revealed to be temperature dependent, with low ambient temperatures associated with decreased 5-HT and DA levels and hypothermia (Bowyer et al., 1992), and high ambient temperatures associated with increased concentrations and hyperthermia (Clausing et al., 1996; Tao et al., 2015).
Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats
2019, Drug and Alcohol DependenceImproved method for optical fiber temperature probe implantation in brains of free-moving rats
2019, Journal of Neuroscience MethodsCitation Excerpt :This mortality rate is notable as the commonly accepted LD50 for intraperitoneally injected MDMA in the rat is 49 mg/kg (Hardman et al., 1973). The results gathered by our improved probe support previous data that high ambient temperatures exacerbate the MDMA-induced hyperthermic response (Gordon et al., 1991; Malberg and Seiden, 1998; Seiden and Sabol, 1996). It is well known that the brain is the most temperature sensitive organ in the body and even small deviations in temperature can have profound negative impacts within the brain (Schiff and Somjen, 1985), thus an effective means of localized thermometry is required to better assess and understand these impacts.
Brain temperature: from physiology and pharmacology to neuropathology
2018, Handbook of Clinical Neurology
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This paper has been reviewed by the Health Effects Research Laboratory, U.S. Environemtal Protection Agency, and approved for publication. Mention of trade names or commmercial products does not constitute endorsement or recommendation for use.
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Work supported in part by National Institute of Drug Abuse IAG RA89-4.