The flinders sensitive line exhibits enhanced thermic responsiveness to nicotine relative to the Sprague-Dawley rat
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Cited by (15)
The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited
2015, European Journal of PharmacologyCitation Excerpt :Other support for increased extracellular cholinergic tone underlying depression-like behaviors comes from specific lines of rats. A selectively bred line of rats with increased sensitivity to acetylcholinesterase, the Flinders Sensitive Line, exhibit an exaggerated behavioral and physiological response to cholinergic agents such as nicotine (Dilsaver et al., 1992). Furthermore, this line exhibits depression-like behaviors including lower startle thresholds (Markou et al., 1994), fulfilling some criteria of face, construct, and predictive validities [see Overstreet (1993) for review].
Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction
2008, Biochemical PharmacologyCitation Excerpt :Variability in function of the adrenergic system seems to underlie many of the differences between these two lines [83]. Similarly, the Flinders sensitive rat line [84] is hypersensitive to anticholinesterase blockers and shows alterations in central nAChR number and function [85,86]. As in human linkage studies, it has been difficult to identify specific genes responsible for differential responses to nicotine in these inbred lines.
Genetic dissection of nicotine-related behaviour: A review of animal studies
2000, Behavioural Brain ResearchThe flinders sensitive line rats: A genetic animal model of depression
1993, Neuroscience and Biobehavioral ReviewsThe flinders sensitive line rat model of depression-25 years and still producing
2013, Pharmacological Reviews