The flinders sensitive line exhibits enhanced thermic responsiveness to nicotine relative to the Sprague-Dawley rat

https://doi.org/10.1016/0091-3057(92)90053-IGet rights and content

Abstract

The Flinders Sensitive Line (FSL) was derived from the Sprague-Dawley rat by selectively breeding animals with heightened sensitivity to an anticholinesterase. The FSL now consistently exhibits enhanced behavioral and physiological responses to the muscarinic agonists relative to its progenitor. The authors now report the FSL exhibits enhanced thermic responsiveness to nicotine relative to the Sprague-Dawley rat. The possible relevance of this finding to investigators interested in the disorders of mood is briefly discussed.

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Cited by (15)

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    Other support for increased extracellular cholinergic tone underlying depression-like behaviors comes from specific lines of rats. A selectively bred line of rats with increased sensitivity to acetylcholinesterase, the Flinders Sensitive Line, exhibit an exaggerated behavioral and physiological response to cholinergic agents such as nicotine (Dilsaver et al., 1992). Furthermore, this line exhibits depression-like behaviors including lower startle thresholds (Markou et al., 1994), fulfilling some criteria of face, construct, and predictive validities [see Overstreet (1993) for review].

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