Ethanol, nicotine, amphetamine, and aspartame consumption and preferences in C57BL/6 and DBA/2 mice

doi:10.1016/0091-3057(94)00354-8

Pharmacology Biochemistry and Behavior

Volume 50, Issue 4, April 1995, Pages 619-626

https://doi.org/10.1016/0091-3057(94)00354-8 Get rights and content

Abstract

Using a two-bottle choice paradigm, adult C57BL/6 and DBA/2 mice (11 males and 10 females per strain) were given access to tapwater and an ascending series of concentrations of ethanol, nicotine, amphetamine, and the artificial sweetener, aspartame. The C57 mice consumed more ethanol, nicotine, and amphetamine, and showed greater preferences for these substances, than did the DBA/2 mice. In contrast, DBAs consumed more and showed greater preference for aspartame than C57s. However, measures of drug and aspartame consumption and preference were moderately intercorrelated when the effects of gender and strain were controlled for. This pattern of results suggests that factors modulating differences between C57BL/6 and DBA/2 mice in ethanol consumption and preference also modulate differences in consumption of nicotine and amphetamine.

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ArticleEthanol, nicotine, amphetamine, and aspartame consumption and preferences in C57BL/6 and DBA/2 mice

Abstract

Neurosci. Biobehav. Rev.

Drug Alcohol Depend.

Pharmacol. Biochem. Behav.

Alcohol

Pharmacol. Biochem. Behav.

Progr. Neuropsychopharmacol. Biol. Psychiatry

Brain Res.

Drug Alcohol Depend.

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Pharmacol. Biochem. Behav.

Brain Res.

Pharmacol. Biochem. Behav.

Alcohol

Alcohol

Gen. Pharmacol.

Voluntary consumption of ethanol in 15 inbred mouse strains

Psychopharmacology

Seven generations of genetic selection for ethanol dependence in mice

Behav. Genet.

Article
Ethanol, nicotine, amphetamine, and aspartame consumption and preferences in C57BL/6 and DBA/2 mice