Fluoxetine-induced inhibition of male rat copulatory behavior: Modification by lesions of the nucleus paragigantocellularis
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2022, Sexual MedicineCitation Excerpt :From a neurological aspect, ejaculation is a process of neurophysiological reflexes regulated by the complex neurophysiological mechanisms, which refers to expulsion of semen from the urethra, including emission, ejaculation and intense pleasure. A basic study showed that the medial preoptic nucleus of the rat hypothalamus and the paraventricular nucleus of the forebrain have a crucial role in the pivotal control of ejaculation.35 Nucleus paragigantocellularis (nPGi) inhibits motor neurons in the lumbosacral region through the release of 5- hydroxytryptamine and yields sustained ejaculatory inhibition via descending pathways.
The neurobiology of the male sexual refractory period
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2016, Behavioural Brain ResearchAnandamide Reduces the Ejaculatory Threshold of Sexually Sluggish Male Rats: Possible Relevance for Human Lifelong Delayed Ejaculation Disorder
2015, Journal of Sexual MedicineCitation Excerpt :These included the medial preoptic area, bed nucleus of the stria terminalis, medial amygdala, the ventromedial nucleus of the hypothalamus, and the midbrain central tegmental field [17]. Later, the nucleus paragigantocellularis (nPGi), located at the brainstem, was found to exert a tonic inhibitory control on the ejaculatory response [18-20]. The nPGi receives neural inputs from several of the ejaculation-related brain activated regions [21], and most serotonergic nPGi neurons project directly to the lumbosacral spinal cord [22] where the spinal ejaculation generator is located.