Cell
Volume 47, Issue 2, 24 October 1986, Pages 277-284
Journal home page for Cell

Article
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

https://doi.org/10.1016/0092-8674(86)90450-2Get rights and content

Abstract

The primary structure of normal abl protein was determined by sequencing the coding region of its cDNA. abl contains two alternative 5′ exons spliced to a common set of 3′ exons to yield the two major abl RNA transcripts. These transcripts initiate in different promoter regions and give rise to proteins that vary in their N-termini. In the human cell line K562, abl is translocated from chromosome 9 to within the bcr gene on chromosome 22. Within the fused bcr-abl gene, abl exon II alternatively splices to two adjacent bcr exons. This phenomenon is seen in many patients with chronic myeloid leukemia.

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    • Impact of BCR-ABL transcript type on outcome in patients with chronic-phase CML treated with tyrosine kinase inhibitors

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