Cell
A dual receptor system is required for basic fibroblast growth factor activity
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Cited by (542)
Regulation of the transcription factor E2F8 gene expression in bovine ovarian cells
2019, Molecular and Cellular EndocrinologyCitation Excerpt :The FGF family regulates several processes including granulosa cell (GC) steroidogenesis in cattle (Vernon and Spicer, 1994; Schreiber and Spicer, 2012; Schreiber et al., 2012) and pigs (Evans et al., 2014), apoptosis (Tilly et al., 1992; Kaipia and Hsueh, 1997), and oocyte maturation (Cho et al., 2008). FGFs share significant homology in their central core amino acid sequences, allowing for binding of high affinity transmembrane tyrosine kinase receptors (FGFR1-4; Klagsbrun and Baird, 1991; Katoh, 2008; Ornitz and Itoh, 2015), through which members of this family signal. Recent studies in cattle have shown that abundance of FGF9 mRNA in GC is greater in small vs large follicles (Schreiber et al., 2012), is less in estrogen-active vs estrogen-inactive follicles (Schütz et al., 2016) and less in GC of cystic vs normal follicles (Grado-Ahuir et al., 2011), and greater in GC than TC of cattle (Schreiber et al., 2012; Schütz et al., 2016).
The FGF21 Receptor Signaling Complex: Klothoβ, FGFR1c, and Other Regulatory Interactions
2016, Vitamins and HormonesCitation Excerpt :It has been determined that these proteins are still exported from cells by a novel energy-dependent mechanism (Florkiewicz, Majack, Buechler, & Florkiewicz, 1995). Nevertheless, all FGFs are capable of functioning extracellularly and mediate biological responses by signaling through a co-receptor system that includes high-affinity cell surface FGFRs possessing intrinsic tyrosine kinase activity, as well as low-affinity cell surface or matrix-associated HSPGs (Klagsbrun & Baird, 1991; Roghani & Moscatelli, 1992). Temporal and tissue-specific expression of the different FGFs, as well as the varying affinities with which they bind multiple receptors, leads to an exceptionally complex pattern of ligand/receptor interactions and cellular biological responses.
In vivo injection of fibroblast growth factor-2 into the cisterna magna induces glypican-6 expression in mouse brain tissue
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