Neurotensin increases extracellular striatal dopamine levels in vivo
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Cited by (31)
Endocannabinoid Signaling in the Striatum
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :This effect also requires activation of group I mGluRs and D2 dopamine receptors, and the role of the NT receptor is most likely stimulation of postsynaptic eCB production. This may be a direct effect or secondary to increased dopamine or glutamate release (Okuma et al., 1983; Chapman et al., 1992; Diaz-Cabiale et al., 2002; Matsuyama et al., 2003). Activation of group I mGluRs also produces eCB-mediated short-term depression in striatal brain regions.
Intra-accumbens shell injections of SR48692 enhanced cocaine self-administration intake in rats exposed to an environmentally-elicited reinstatement paradigm
2009, Brain ResearchCitation Excerpt :In fact, it has been suggested that NT receptors are mainly targeted to presynaptic sites where they can play a role in the regulated secretion and/or retrograde signaling (Pickel et al., 2001). Interestingly, this presynaptic localization of NT1 receptors is associated with increased DA release after local NT injection (Chapman et al., 1992). We, therefore, propose that the increase in cocaine self-administration, observed after blockade of NT receptors, might be due to a disruption in the interactions of presynaptic NT1 and D2 receptors.
Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling
2008, NeuropharmacologyCitation Excerpt :Still, this hypothesis cannot be ruled out at present. Finally, since NTS1 and D2 receptors are colocalized within single axon terminals, NT may simply potentiate dopamine release by antagonizing the function of presynaptic D2 autoreceptors, as has previously been suggested (Chapman et al., 1992; Diaz-Cabiale et al., 2002; Delle Donne et al., 2004). Indeed, it is well documented that NT stimulates dopamine release in striatal slices (Okuma et al., 1983; Battaini et al., 1986; Hetier et al., 1988).
Brain levels of neuropeptides in human chronic methamphetamine users
2007, NeuropharmacologyCitation Excerpt :These neuropeptides have also been shown to alter activity of DA pathways known or suspected to influence motor functions, emotions, and addictive behavior (DYN (Reid et al., 1988; Steiner and Gerfen, 1998); MENK (Steiner and Gerfen, 1998); NPY (Midgley et al., 1994); NT (Wagstaff et al., 1996b); SP (Reid et al., 1988)). Specifically, application of NT (Chapman et al., 1992) or SP (Tang et al., 1998) are reported to be excitatory, while DYN and MENK are reported to be inhibitory on striatal dopaminergic activity (Steiner and Gerfen, 1998). Consequently, there are actions both by drugs of abuse and these neuropeptide systems on DA pathways (Ervin et al., 1981; Steiner and Gerfen, 1998).
Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice
2006, Neuroscience Letters