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Immediate hypersensitivity reactions of the heart: Reduction of tachycardia and arrhythmias by the SRS-A antagonist FPL 55712

https://doi.org/10.1016/0162-3109(80)90010-7Get rights and content

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    Generally, pyrethrins and pyrethroids effects sodium channel by activation at lower threshold; which result in prolonged flow of sodium currents into neurons (Evans, 1984; Sonderlund, 1995). The mode of action of Sabadila (Schoenocanlon offiicinale) is similar to that of pyrethrins, as it affects the voltage dependent sodium channels of nerve axon (Ohta, 1973; Levi et al., 1980). Nicotine poisoning symptoms follow the general sequence of excitation, convulsions, paralysis, death and mimics as a part of the action of acetylcholine by interacting with the nicotine acetylcholine receptor as receptor fails to distinguish between nicotine and acetylcholine (Richards and Cutkomp, 1945).

This study was supported by the U.S. Public Health Service grant (GM 20091)

1

J.A.B. is a predoctoral trainee in pharmacology, supported by grant GM 07547.

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