Regular articleDepletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats
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Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus
2016, European Journal of Medicinal ChemistryCitation Excerpt :Moreover, to determine the postsynaptic 5-HT1A receptor agonistic effects of the tested compounds, their ability to induce lower lip retraction (LLR) in rats was tested. It is commonly accepted that the 8-OH-DPAT induced LLR in rats depends on stimulation of postsynaptic 5-HT1A receptors and this effect is inhibited by WAY100635 [37,38,52–54]. Hence, the ability of the tested compounds to inhibit the 8-OH-DPAT-induced LLR was regarded as postsynaptic 5-HT1A receptor antagonist activity.
Serotonin 5-HT<inf>1A</inf> receptor in infancy-onset aggression: Comparison with genetically defined aggression in adult rats
2013, Behavioural Brain ResearchCitation Excerpt :The maximal temperature difference was calculated for further statistical analysis. Simultaneously, using digital camera the specific for rat 5-HT1A receptor-mediated Lower Lip Retraction (LLR) [37] was registered. The degree of retraction was estimated by three independent investigators using five-score system [27].
Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1
2011, European Journal of Medicinal ChemistryCitation Excerpt :Since the hypothermia induced by the examined compounds (4l, 4n or 6b) was not attenuated by WAY 100635, this suggests that this effect was not mediated through 5-HT1A somatodendritic receptors. Administration of 8-OH-DPAT induces lower lip retraction (LLR) in rats, an effect connected with the stimulation of postsynaptic 5-HT1A receptors [44,45]. LLR induced by 8-OH-DPAT is abolished by 5-HT1A receptor antagonists e.g., WAY 100635 or WAY 100135 [43,46].
Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT<inf>1A</inf> receptor agonist with potential antidepressant and anxiolytic activity
2010, European Journal of Medicinal ChemistryCitation Excerpt :To determine the postsynaptic 5-HT1A receptor agonistic effect of the tested compounds, their ability to induce lower lip retraction (LLR) in rats was tested. It had been commonly accepted that the 8-OH-DPAT-induced LLR in rats depended on stimulation of postsynaptic 5-HT1A receptors [19,20]. Moreover, it was shown that the later symptom was sensitive to a 5-HT1A receptor antagonist [18].