Regular article
CGP 36742: The first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys

https://doi.org/10.1016/0163-1047(93)90729-2Get rights and content

The learning capacity of experimental animals in cognitive tests can be improved by blockade of the GABAB receptors. After treatment with the GABAB antagonist CGP 36742, mice performed better in a passive-avoidance test; rats did likewise in a partner-recognition test, and rhesus monkeys also in a “conditional spatial color” task. The effects demonstrated in these three different species and covering diverse manifestations of learning and memory give reason to hope that this new active principle may prove therapeutically useful.

References (33)

  • CastellanoC. et al.

    GABAergic modulation of memory

  • CastellanoC. et al.

    Post-training systemic and intraamygdala administration of the GABAB agonist Baclofen impairs retention

    Behavioral and Neural Biology

    (1979)
  • DaviesC.H. et al.

    GABAB autoreceptors regulate the induction of LTP

    Nature

    (1991)
  • DutarP. et al.

    A physiological role for GABAB receptors in the central nervous system

    Nature

    (1988)
  • GaffanD. et al.

    Place memory and scene memory: Effects of fornix transsections in the monkey

    Experimental Brain Research

    (1989)
  • GehanE.

    A generalized Wilcoxon test for comparing arbitrarily single censored samples

    Biometrika

    (1980)
  • Cited by (0)

    1

    The results were presented at the Second International GABAB Meeting in Interlaken, Switzerland, October 21–23, 1992.

    View full text