Research reportDopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders
References (35)
- et al.
Association of dopamine D2 receptor molecular variant with schizophrenia
Lancet
(1994) - et al.
Association of structural polymorphism of the dopamine D2 receptor gene and alcoholism
Biochem. Biophys. Res. Commun.
(1994) - et al.
A structural polymorphism of human dopamine D2 receptor, D2(Ser311 → Cys)
Biochem. Biophys. Res. Commun.
(1993) - et al.
Polymorphic DNA marker on X chromosome and manic depression
Lancet i
(1987) - et al.
Linkage of bipolar affective disorders to markers on chromosome 11 p is excluded in a second lateral extension of Amish pedigree 110
Genomics
(1991) - et al.
A serine to glycine substitution at position 9 in the extracellular N-terminal part of the dopamine D3 receptor protein: no role in the genetic predisposition to bipolar affective disorder
Psychiatry Res.
(1993) Signal sorting and amplification through G protein-coupled receptors
Neuron
(1989)- et al.
Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility
Genomics
(1992) - et al.
Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR
Genomics
(1992)
Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees
Nature Genet.
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking
Nature Genet.
Approaches to the genetics of affective disorders
Ann. Med.
Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11
Am. J. Psychiatry
Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees
Nature
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
Nature Genet.
Bipolar affective disorders linked to DNA markers on chromosome 11
Nature
Cited by (105)
Application of Research Domain Criteria to childhood and adolescent impulsive and addictive disorders: Implications for treatment
2018, Clinical Psychology ReviewCitation Excerpt :However, findings have often been inconsistent. For example, studies focusing on DRD2 and DAT1 – genes listed in the current RDoC matrix on initial responsiveness to reward attainment – have yielded equivocal results within the context of specific disorders including substance and behavioral addictions (Blomqvist, Gelernter, & Kranzler, 2000; Comings, Muhleman, Ahn, Gysin, & Flanagan, 1994; Comings et al., 1996; Lohoff et al., 2010; Moyer et al., 2011; Sweitzer, Donny, & Hariri, 2012; Ueno et al., 1999; van der Zwaluw et al., 2009), bipolar disorder (Gomez-Casero, Perez de Castro, Saiz-Ruiz, Llinares, & Fernandez-Piqueras, 1996; Greenwood et al., 2013; Greenwood, Schork, Eskin, & Kelsoe, 2006; Keikhaee et al., 2005; Manki et al., 1996; Massat et al., 2002; Pinsonneault et al., 2011; Wang et al., 2014) and ADHD (Barr et al., 2001; Chen et al., 2003; Greenwood et al., 2013; Kustanovich et al., 2004; Lasky-Su et al., 2008; Nyman et al., 2007). Given the somewhat conflicting findings from disorder-specific studies, an alternative research approach has been to identify genetic variants associated with specific aspects of reward processing – e.g., responses to reward attainment.
Molecular biomarkers of depression
2016, Neuroscience and Biobehavioral ReviewsAssociation of DRD2 gene polymorphisms with mood disorders: A meta-analysis
2012, Journal of Affective DisordersCitation Excerpt :A P value of less than 0.05 was considered statistically significant, and all the P values were two sided. Characteristics of studies investigating the association of DRD2 gene polymorphisms with mood disorders are presented in Table 1 (Huuhka et al., 2008; Kõks et al., 2006; Leszczyńska-Rodziewicz et al., 2005; Cusin et al., 2002; Massat et al., 2002; Heiden et al., 2000; Gorwood et al., 2000; Li et al., 1999; Savoye et al., 1998; Furlong et al., 1998; Stöber et al., 1998; Golimbet et al., 1998; Manki et al., 1996; Sasaki et al., 1996; Arinami et al., 1996; Pérez de Castro et al., 1995; Craddock et al., 1995; Nöthen et al., 1992). There were 9523 papers relevant to the searching word (PubMed: 569; Elsevier Science Direct: 8416; Cochrane Library: 9; CBM: 15; CNKI: 294; and Wanfang: 22).
Depression and the role of genes involved in dopamine metabolism and signalling
2010, Progress in NeurobiologyDopamine D<inf>3</inf> receptor gene variation: Impact on electroconvulsive therapy response and ventral striatum responsiveness in depression
2013, International Journal of Neuropsychopharmacology