Genotoxic effects of estrogens
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Cited by (231)
Carcinogenic potential of fluorinated estrogens in mammary tumorigenesis
2020, Toxicology LettersCitation Excerpt :Human estrogens have been implicated in the etiology of breast and endometrial cancers (Henderson et al., 1998; Harris et al., 1992; Zumoff, 1993), and exposure of laboratory animals to human estrogens causes renal, mammary and uterine tumors (IARC et al., 1979; Liehr, 1990; Li et al., 1995). Although the mechanisms underlying estrogen-induced carcinogenesis have not been fully elucidated, there is evidence that both estrogen receptor (ER)-mediated proliferative processes and ER-independent DNA damage (Liehr, 1990; Fishman et al., 1995; Santen et al., 2015) are significant factors in the process. The tumorigenic activity of human and synthetic estrogens has been previously measured in terms of renal tumor incidence in male Syrian hamsters (Kirkman, 1959; Liehr, 1983 and 1984; Liehr et al., 1986a,1986b; Li et al., 1995).
How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?
2019, DNA RepairCitation Excerpt :Fresh evidence also implicates the genotoxic effects of tissue-specific hormones such as oestrogen active especially in the breast or ovary. Evidence that oestrogen metabolites induce DNA damage is longstanding (reviewed for eg. in, [82]); recent evidence now suggests that R-loop formation is a major source of oestrogen-induced genotoxicity [83]. Another line of enquiry arises from the recent observation that endogenous metabolites like aldehydes, which are turned over differentially through cellular metabolism in different tissues, are able to trigger DNA damage, induce BRCA2 haploinsufficiency accompanied by the outgrowth of genomically unstable progeny [57], or even cell death [84] in BRCA-mutant cells.
Proteomic analysis of oxidized proteins in the brain and liver of the Nile tilapia (Oreochromis niloticus) exposed to a water-accommodated fraction of Maya crude oil
2019, Ecotoxicology and Environmental SafetyCytogenetic biomarkers in detection of genotoxic effects of gestagens in peripheral blood lymphocytes in vitro and in vivo
2016, European Journal of Medical GeneticsCYP1B1 and hormone-induced cancer
2012, Cancer LettersCitation Excerpt :This has severely limited any ability to assess associations between these polymorphisms and risk. The genetic basis of carcinogenesis in endometrial cancer is not well understood; however, metabolic conversion of oestrogens to 4-hydroxyoestrogens has been postulated as a major factor in endometrial carcinogenesis [10,104]. Administration of 4-OH E2 induces DNA damage and endometrial adenocarcinoma in CD-1 mice [105].