Research paper
The effects of interleukin-1β on the activity of adrenal, splenic and renal sympathetic nerves in the rat

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Abstract

The effects of intravenous (i.v.) administration of recombinant human interleukin-1β (rhIL-1β) on the activity of adrenal, splenic and renal sympathetic nerves were observed in urethane-anesthetized rats. An i.v. injection of IL-1β in doses of 10 pg-20 ng per animal (300–400 g, b.w.) resulted in a dose-dependent increase in the activity of the adrenal and splenic nerves, which lasted for more than 2–6 h. On the other hand, the activity of renal nerves showed a transient increase which was followed by a long-lasting suppression after injection of rhIL-1β (100 pg, i.v.). An i.v. injection of cyclooxygenase inhibitors (6 mg ibuprofen or 20 mg sodium salicylate) suppressed almost completely the rhIL-1β (100 pg)-induced activity in adrenal and splenic nerves. Although rhLI-1β (100 pg, i.v.) produced a fall in arterial blood pressure, baroreceptor denervation did not affect the excitatory responses of the adrenal and splenic nerves to rhIL-1β. The results suggest the regional differentiation of activity in the visceral sympathetic nerves in response to rhIL-1β. The rhIL-1β-induced activation of splenic sympathetic nerves implicates their involvement in the modulation of immunity by brain.

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