Research paperLymphocyte adhesion to brain capillary endothelial cells in vitro
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2011, European Journal of PharmacologyCitation Excerpt :LPS can increase blood-brain barrier permeability through many different pathways (Jaeger et al., 2009; Wispelwey et al., 1988; Xaio et al., 2001) (Fig. 1: pathway 5). It can enhance endocytosis by brain endothelial cells (Banks et al., 1999) and facilitate immune cell trafficking (de Vries et al., 1994; Persidsky et al., 1997). Furthermore, LPS can stimulate brain endothelial cells to secrete cytokines (Reyes et al., 1999; Verma et al., 2006).
The blood-brain barrier and immune function and dysfunction
2010, Neurobiology of DiseaseCitation Excerpt :The human immunodeficiency virus and its surface coat glycoprotein gp120 can enter the brain by this mechanism and LPS enhances the transport of both of them across the BBB (Dohgu and Banks, 2008). Immune cell adhesion and trafficking are enhanced by LPS (De Vries et al., 1994; Persidsky et al., 1997). Several saturable transport systems, including those for insulin and cisplatin, are increased whereas others, including that of tumor necrosis factor-alpha, are not (Banks et al., 2008; Minami et al., 1998; Osburg et al., 2002).
Lipopolysaccharide alters the blood-brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer's disease
2009, Brain, Behavior, and ImmunityCitation Excerpt :One circulating factor that could be acting at the BBB to alter I-Aβ transport is LPS itself. LPS can act directly on brain endothelial cells to induce release of cytokines and to increase lymphocyte adhesion (De Vries et al., 1994; Verma et al., 2006). We tested a series of concentrations of LPS in an in vitro monolayer model, with the highest dose of LPS disrupting the monolayer model as shown by a decrease in TEER.
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