Trends in Pharmacological Sciences
Are methylxanthine effects due to antagonism of endogenous adenosine?
References (13)
Cyclic Nucleotides in the Central Nervous System
(1977)Med. Biol.
(1978)- et al.
Naunyn-Schmiedebergs Arch. Pharmacol.
(1975)
Cited by (361)
Caffeine intake and its influences on heart rate variability recovery in healthy active adults after exercise: A systematic review and meta-analysis
2022, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :The different behavior of CAF responses to intake about its typical consumption may be connected to an adjustment of the adenosine receptors [40]. In 1979, Fredholm [41] revealed an increase in the number of adenosine binding sites in the cerebral cortex of rats treated for two weeks with 10 mg/kg/day of CAF. This response supports the theory that chronic CAF ingestion might result in newly created adenosine receptors, partly reducing the blocking action of CAF and thus lessening its stimulant effects [41].
Beneficial Roles of Caffeine in Sports Nutrition and Beverage Formulations
2017, Sustained Energy for Enhanced Human Functions and ActivityCardiac electrophysiology of patients with spinal cord injury
2017, Heart RhythmCitation Excerpt :Several case series describe use of methylxanthines as preventive therapy for dangerous bradyarrhythmias. Methylxanthines directly antagonize the effects of endogenous adenosine at a variety of receptor subtypes, including the A1A receptor found in the sinoatrial node and AV node.46,47 At serum levels approaching toxicity, methylxanthines also inhibit phosphodiesterase and thereby increase intracellular cyclic adenosine monophosphate levels, enhancing the effects of the SNS and contributing to the development of SVTs.48
Low, but not high, dose caffeine is a readily available probe for adenosine actions
2017, Molecular Aspects of MedicineA review of caffeine's effects on cognitive, physical and occupational performance
2016, Neuroscience and Biobehavioral ReviewsCitation Excerpt :However, since Weiss and Laties did so in 1962 there have been only a few attempts to summarize caffeine’s effects on both physical and cognitive function (Goldstein et al., 2010; Rogers and Dinges, 2005; Sökmen et al., 2008) and these latter reviews focussed on issues of interest to the sporting community. Nevertheless, it is clear that there are doses of caffeine available in foods and beverages that raise plasma concentration to levels which block adenosine receptors (Fredholm, 1979, 1995; Fredholm et al., 1999), and exert central nervous system (CNS) effects, to a degree that impacts both cognitive and physical function. It is also evident that there are many occupational settings, as well as sporting and leisure activities, where optimal physical and cognitive function is critical for performance success, safety and productivity.