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Airway epithelium-derived inhibitory factor

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Abstract

Various bronchoactive agents can induce the release from the airway epithelium of an inhibitory substance that is able to relax certain tissues including rat aorta and possibly also airway smooth muscle. This substance, whose existence has recently been confirmed using a new bioassay system, is distinct from nitric oxide (EDRF) and is also known to be non-prostanoid in nature. Roy Goldie and colleagues describe the properties of this factor, and its potential clinical significance.

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    R.G. Goldie is a Senior Research Fellow at the Department of Pharmacology, University of Western Australia, Perth, Nedlands, WA 6009, Australia, and L. B. Fernandes has recently completed PhD studies in this Department. S. G. Farmer is a Staff Scientist at Nova Pharmaceutical Corporation, 6200 Freeport Centre, Baltimore, MD 21224-2788, USA. D. W. P. Hay is a Senior Investigator at the Department of Pharmacology, Smith Kline Beecham Laboratories, King of Prussia, PA 19406-0939, USA.

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