Trends in Pharmacological Sciences
Special featureRodbell and Gilman win 1994 Nobel Prize for Physiology and Medicine
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Advances in the molecular level understanding of G-protein coupled receptor
2023, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Although, many GPCRs display basal activity, complete activation of GPCRs is mediated by heteromeric G proteins, G-protein coupled receptor kinase (GRK)-mediated phosphorylation and arrestin coupling.1,2 Historically, research work by several pioneers such as Rodbell and Gilman led to the discovery of heteromeric G proteins, followed by discoveries of GRKs, arrestins, rhodopsin kinase and β-adrenergic receptor kinase (βARK).3,4 Recently, advanced molecular techniques including NMR, single molecule fluorescence, X-ray crystallography and cryo electron microscopy have unfolded fascinating molecular details of more than 350 GPCRs5–7 and this family of proteins display one of the most important pharmacological potential and therapeutic target.8
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