Trends in Neurosciences
ViewpointCholinergic mechanisms in learning, memory and dementia: a review of recent evidence
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2022, Chemico-Biological InteractionsCritical role of hippocampal muscarinic acetylcholine receptors on memory reconsolidation in mice
2021, Neurobiology of Learning and MemoryCitation Excerpt :It is known that there are conditions (e.g. the presentation of a specific reminder of the stored experience) or requirements necessary for the reconsolidation process to take place such as: the strength of the training (Boccia et al., 2004; Suzuki et al., 2004), the age of memory (Boccia, Blake, Acosta, & Baratti, 2006; Milekic & Alberini, 2002), the duration of CS (Pedreira & Maldonado, 2003), the mismatch between what is expected and what actually happens (Exton-McGuinness, Lee, & Reichelt, 2015; Mackintosh, 1975; Pearce & Bouton, 2001; Pedreira, Pérez-Cuesta, & Maldonado, 2004) [for a review see, Fernández, Boccia et al., 2016; Fernández, Bavassi et al., 2016]. Over the years, many studies have shown that cholinergic antagonists were responsible for the behavioral impairment observed in different learning tasks (Boccia et al., 2004, 2006; Decker & McGaugh, 1991; Fibiger, 1991; Gallagher & Colombo, 1995). Moreover, there is no discussion on the necessity of endogenous ACh in the different stages of memory processes such as consolidation, retrieval, extinction and memory reconsolidation in order to take place (Boccia, Blake, Acosta, & Baratti, 2003, 2004, 2009).
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2019, NeuroscienceCitation Excerpt :Therefore, the development of new drugs with better efficacy is warranted. Cholinergic neurotransmission in the cerebral cortex and hippocampus is a key mediator of learning and memory (Fibiger, 1991), and cholinergic dysfunction is commonly reported in patients with AD, DLB, and schizophrenia. In AD and DLB, the basal forebrain cholinergic neurons that innervate the cerebral cortex and hippocampus are selectively degenerated (Whitehouse et al., 1982; McKeith et al., 1996).