Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

doi:10.1016/0166-2236(94)90005-1

Trends in Neurosciences

Volume 17, Issue 6, June 1994, Pages 228-233

https://doi.org/10.1016/0166-2236(94)90005-1 Get rights and content

Abstract

The striatum is viewed as a structure performing fast neurotransmitter-mediated operations through somatotopically organized projections to medium-size spiny neurons. This view is contrasted with another view that depicts the striatum as a site of diffuse modulatory influences mediated by cholinergic interneurons and by dopamine and $N- methyl- d -aspartate$ receptors. These two operational and organizational modes both contribute, through their mutual interaction, to the function of basal ganglia. Detailed knowledge of the neural mechanisms by which such interactions take place and are expressed into behaviour, can provide new insight into the physiopathology and new clues for therapy of disorders of basal ganglia.

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ReviewsModulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

Abstract

Trends Neurosci.

Trends Neurosci.

Trends Neurosci.

Trends Neurosci.

Neuroscience

Brain Res.

Brain Res.

Brain Res.

Brain Res. Bull.

Neuroscience

Neuroscience

Brain Res.

Neuroscience

Neuroscience

Neuroscience

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Eur. J. Pharmacol.

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Brain Res.

Mol. Brain Res.

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Eur. J. Pharmacol.

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Pharmacol. Ther.

Neurology

Annu. Rev. Neurosci.

J. Physiol.

Annu. Rev. Neurosci.

Adv. Neurol.

Arzneimit. Forsch. Drug Res.

J. Neurosci.

Reviews
Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions