Short communicationKindling facilitates acquisition of discriminative responding but disrupts reversal learning of the rabbit nictitating membrane response
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Cited by (19)
Amygdaloid kindling is anxiogenic but fails to alter object recognition or spatial working memory in rats
2008, Epilepsy and BehaviorCitation Excerpt :Physiological studies have provided evidence for mixed effects on amygdaloid neurons after kindling, both hyperexcitability [65] and increased inhibitory tone [66]. Similarly, in the paradigm involving conditioning of the nictitating membrane (NM) in rabbits, kindling facilitates acquisition of the NM response, resembling the effects of induction of long-term potentiation, but impairs reversal learning, resembling the effects of hippocampal lesions [67]. Thus, perforant path kindling produces both enhanced hippocampal processing and, at the same time, a functional lesion of the hippocampal formation.
The mnemonic effects of kindling
2000, Neuroscience and Biobehavioral ReviewsManipulation of NMDA-receptor activity alters extinction of an instrumental response in rats
1998, Physiology and BehaviorHippocampal synaptic plasticity as a biological substrate underlying episodic psychosis
1995, Biological PsychiatryLearning and retention in pentylenetetrazol-kindled rats
1993, European Neuropsychopharmacology
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