Immunohistochemical localization of substance P, vasoactive intestinal polypeptide and gastrin-releasing peptide in vas deferens and seminal vesicle, and the effect of these and eight other neuropeptides on resting tension and neurally evoked contractile activity
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Cited by (67)
Anatomy and physiology of genital organs - men
2015, Handbook of Clinical NeurologyCitation Excerpt :These observations led to the suggestion, in contrast to the conventional view of the organization of pelvic autonomic pathways, that sympathetic innervation to the prostate includes both adrenergic and cholinergic components. In addition to adrenergic and cholinergic commands, peptidergic (VIP and NPY) and purinergic (ATP) regulation of NA action on the genital tract has been demonstrated in laboratory animals (Stjernquist et al., 1983; Allcorn et al., 1986; Ventura et al., 2003). In humans, disruption of sympathetic pathways supplying the bladder neck, ductus deferens, and prostate is widely accepted to be the cause of postoperative anejaculation or retrograde ejaculation.
Spinal neurons involved in the control of the seminal vesicles: A transsynaptic labeling study using pseudorabies virus in rats
2009, NeuroscienceCitation Excerpt :Sympathetic non-adrenergic nerves were believed to provide secretomotor innervation to the glandular epithelium, while smooth muscle contraction and, consequently, expulsion of the glandular contents during seminal emission, are considered to be largely under sympathetic–noradrenergic control. There was a consensus that parasympathetic innervation of the glands is limited (Alm et al., 1978, 1980, 1981; Vaalasti et al., 1980, 1986; Gu et al., 1983; Stjernquist et al., 1983, 1987; Adrian et al., 1984; Higgins and Gosling, 1989; Lange and Unger, 1990; Yuri, 1990; Crowe et al., 1991; Properzi et al., 1992; Iravani and Zar, 1994; Jen et al., 1995, 1996; Tainio, 1995; Afonso et al., 1996; Hedlund et al., 1996; Chow et al., 1997). However, with retrograde tracing techniques and immunohistochemistry, Kepper and Keast (1997) found that sympathetic axons with tyrosine hydroxylase and NPY supplied vascular and nonvascular smooth muscle of rats seminal vesicle, whereas parasympathetic, cholinergic NPY terminals were associated with the glandular epithelium.
Role of the neurokinin-1 receptors in ejaculation in anesthetized rats
2009, Journal of Sexual MedicineCitation Excerpt :The present findings are in favor of a functional role for spinal NK1 receptors expressed in LSt neurons in the expression of ejaculation, possibly by modulating sympathetic preganglionic neurons that control the tone of the smooth muscle cells of the sexual glands. In different species, SP-containing nerve fibers have been found in male genital organs, including vas deferens and seminal vesicles (for review, see [5]), and in guinea pig; SP facilitated the contractile response of these organs to in vitro electrical field stimulation [6]. However, data collected in isolated rat vas deferens strongly suggest the NK2 receptor as the main mediator of such tachykinin contractile effects [29].
Sildenafil Citrate Inhibits Agonist Induced Contractions in Isolated Rat Seminal Vesicles
2006, Journal of UrologyTachykinins and tachykinin receptors: Effects in the genitourinary tract
2005, Life Sciences