Parallel bioassay of 27 bombesin-like peptides on 9 smooth muscle preparations. Structure-activity relationships and bombesin receptor subtypes
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Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells
2016, PeptidesCitation Excerpt :Third, our results demonstrated the four chiral-diazepines are fully efficacious BRS-3 agonists for activating phospholipase C in cells containing h,r,m-BRS-3; and that they were selective for BRS-3, not activating activate h,r,m-GRPR/NMBR, even at concentrations up to 3000 nM. Previous studies report wide variation in the affinities of peptide agonists/antagonists for GRPR/NMBR in different species [8,9,14,22,28,34,61,63,64], as well as their potency/efficacy for activating GRPR/NMBR and functioning as an agonist, partial agonist or antagonist in different species [8,9,22,63,64]. Much less information is available for the BRS-3-receptor, because the endogenous ligand is unknown [13,30].
Neuropeptides as lung cancer growth factors
2015, PeptidesCitation Excerpt :They are secreted from neurons upon depolarization and diffuse to adjacent cells where they bind to G protein-coupled receptors (GPCR). Injection of bombesin (BB), a 14 amino acid peptide [13], into the rat CNS causes hyperglycemia [6]. Injection of neurotensin (NTS), a 13 amino acid peptide [7], into the rat CNS causes hypothermia [57].
The role of bombesin and bombesin-related peptides in the short-term control of food intake
2013, Progress in Molecular Biology and Translational ScienceThe structures of four bombesins and their cloned precursor-encoding cDNAs from acid-solvated skin secretion of the European yellow-bellied toad, Bombina variegata
2012, PeptidesCitation Excerpt :The structural diversity of bombesin peptides in the skin secretions of amphibians, demonstrated here in B. variegata and in previous studies of other species [5,6,17], increases the likelihood that in the event of a predator encounter, some components of the defensive secretion will find an appropriate target receptor in the tissues of the predator and cause an effect that is of a life-preserving benefit to the amphibian. Although mammalian bladder and uterus smooth muscle has been employed here in a model bioassay, GRP/NMB receptors have a much wider tissue distribution in mammals [7] and presumably also in sub-mammalian vertebrates such as birds, reptiles, other amphibians and fishes, that also prey upon frogs/toads. Little however is known about receptor types and their distribution in these taxa.
Autonomic control of gut motility: A comparative view
2011, Autonomic Neuroscience: Basic and Clinical