Inhibition by VIP and atriopeptin II on the field stimulation evoked release of [3H]noradrenaline in the rat portal vein

doi:10.1016/0167-0115(91)90235-9

Regulatory Peptides

Volume 33, Issue 3, 17 May 1991, Pages 331-337

https://doi.org/10.1016/0167-0115(91)90235-9 Get rights and content

Abstract

The modulatory effects of vasodilatory peptides on noradrenaline release from sympathetic nerve terminals have been studied in the rat portal vein model.

Transmural field stimulation of the longitudinally mounted vein preparation evoked concomitant increases in the [³H]noradrenaline overflow and the integrated tension. Both responses were abolished by guanethidine or tetrodotoxin, whereas only the tension response was blocked by phentolamine.

CGRP and VIP, both being present in intramural nerve fibers in the rat portal vein, were compared with atriopeptin II for modulatory effects. CGRP (100 nM) had no effect on the overflow of [³H]noradrenaline or the integrated tension response to transmural stimulation. VIP (30 nM) and atriopeptin II (30 nM) both caused significant reductions of both [³H]noradrenaline overflow and the integrated tension.

These results indicate that the decreased tension response to transmural stimulation in the presence of VIP or AP II reflects the sum of both pre- and postsynaptic inhibitions.

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Inhibition by VIP and atriopeptin II on the field stimulation evoked release of [3H]noradrenaline in the rat portal vein

Abstract

Neuroscience

J. Auton. Nerv. Syst.

Regul. Pept.

Life Sci.

Regul. Pept.

Physiology and pathophysiology of atrial peptides

Am. J. Physiol.

Relaxant effects of vasoactive intestinal peptide and peptide histidine isoleucine in human and bovine pulmonary arteries

Blood Vessels

Calcitonin gene-related peptide: a review of its biology and relevance to the cardiovascular system

Endothelium-derived relaxing and contracting factors

FASEB J.

Neuropeptide Y (NPY) reduced field stimulation-evoked release of noradrenaline and enhances force of contraction in the rat portal vein

Naunyn Schmiedebergs Arch. Pharmacol.

Peripheral pre-junctional opioid receptors in cardiovascular control

Structure and function of atrial natriuretic peptides

Clin. Chem.

Inhibition by VIP and atriopeptin II on the field stimulation evoked release of [³H]noradrenaline in the rat portal vein