The purification and sequence analysis of an avian neuromedin U
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Cited by (37)
The neuromedin U system: Pharmacological implications for the treatment of obesity and binge eating behavior
2023, Pharmacological ResearchOverviews of avian neuropeptides and peptides
2022, Sturkie's Avian PhysiologyPurification and identification of native forms of goldfish neuromedin U from brain and gut
2019, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In this study, we determined the native molecular forms of NMU in the brain and gut of goldfish. Native NMU has been identified from several species [5–7,10–12]. In tetrapods, NMU comprises 23 or 25 amino acids and is amidated at the C-terminus.
Characterization of neuromedin U (NMU), neuromedin S (NMS) and their receptors (NMUR1, NMUR2) in chickens
2018, PeptidesCitation Excerpt :The deduced amino acid sequences of chicken NMU-9 and NMU-25 are identical to those of NMU-9 and NMU-25 purified from chicken intestine by O’Harte et al. [10] and Domin et al. [11], respectively. Interestingly, O’Harte et al. reported that NMU-9 is the predominant form [10], whereas Domin et al. (1992) reported that only NMU-25 could be purified from chicken intestine [11]. In this study, we found that within the chicken NMU precursor, cNMU-9 and cNMU-25 are flanked by dibasic/monobasic residues (Fig. 1), which are conserved in nearly all vertebrate species examined, thus, it is likely that as in some mammalian species [20], both forms of NMU could be produced in chickens.
Cloning and expression patterns of neuromedin U and its receptors in pigs
2017, NeuropeptidesCitation Excerpt :Neuromedin U (NMU) is a highly conserved neuropeptide first isolated from porcine spinal cord that facilitates uterine smooth muscle contraction and increases blood pressure in rats (Minamino et al., 1985). NMU has been studied in several species, including guinea pigs (Domin et al., 1986), rats (Domin et al., 1986), Australasian tree frogs (Salmon et al., 2000), rabbits (Kage et al., 1991), chickens (O'Harte et al., 1991), goldfish (Maruyama et al., 2008), avian species (Domin et al., 1992), and humans (Austin et al., 1995; Domin et al., 1986). It must be noted that there may be differences in gene expression between species.
- 1
Present address: Department of Growth Regulation, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, UK.
- 2
Present address: Laboratory of Protein Structure, National Institute For Medical Research, Mill Hill, London NW7 1AA, UK.