A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells
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Cited by (80)
Highly potent antiobesity effect of a short-length peptide YY analog in mice
2017, Bioorganic and Medicinal ChemistryCitation Excerpt :NPY family receptors include six subtypes (Y1–Y5 and y6) in mammals. The function of Y3 is still controversial,5–7 and the y6 gene is not expressed in primates.8–10 Therefore, most pharmacological studies involving NPY family receptors have been conducted for Y1, Y2, Y4, and Y5 subtypes, which showed that they have unequal distributions and different ligand affinities.11–14
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties
2011, Comparative Biochemistry and Physiology - B Biochemistry and Molecular BiologyCitation Excerpt :Comparisons of a broad range of species have demonstrated that the first jawed vertebrate had two NPY-family peptides, NPY and peptide YY (PYY), and no less than seven receptors. The receptor subtypes are named Y1 through Y8 with Y3 missing (it does not exist as a separate gene product) (Herzog et al., 1993; Jazin et al., 1993). Both the peptide genes and several of the receptor genes were multiplied as a result of two tetraploidizations that took place in early vertebrate evolution (Soderberg et al., 2000; Larhammar et al., 2004; Larsson et al., 2008; Salaneck et al., 2008; Sundström et al., 2008; Larsson et al., 2009), often referred to as 2R for two rounds of genome doubling (Dehal and Boore, 2005; Nakatani et al., 2007; Putnam et al., 2008).
Hungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction
2009, Molecular and Cellular EndocrinologyOverview and History of Chemokines and Their Receptors
2005, Current Topics in MembranesCitation Excerpt :CXCR3 is also expressed in a subpopulation of neurons in various cortical and subcortical regions of the brain (Coughlan et al., 2000; Xia et al., 2000) and in astrocytes and microglia (Biber et al., 2002). CXCR4 was initially cloned by several laboratories (Federsppiel et al., 1993; Herzog et al., 1993; Jazin et al., 1993; Nomura et al., 1993) and identified as the orphan receptor LESTR by one group of investigators (Loetscher et al., 1994a). This receptor was later identified as fusin, the co‐receptor (with CD4) for syncytium‐inducing laboratory strains of HIV‐1 (Feng et al., 1996).
The Y<inf>1</inf> receptor subtype mediates the cardiovascular changes evoked by NPY administered into the posterior hypothalamic nucleus of conscious rat
2004, Brain ResearchCitation Excerpt :The log(EC50) for each peptide was then plotted against the averaged log's of the reported IC50's and Ki's of each peptide for the Y1, Y2, Y4 and Y5 receptor subtypes [3,10,11,16,19,22,35,37]. Since the Y6 receptor subtype does not exist in the rat [5,32], and the existence of the Y3 receptor is in question and has yet to be cloned [15,17], these two Y receptor subtypes were not included in the correlations. The greatest degree of correlation was found to exist for the Y1 and Y5 receptor subtypes.