Elsevier

Regulatory Peptides

Volume 62, Issues 2–3, 23 April 1996, Pages 161-166
Regulatory Peptides

Regular paper
Characterization of gene expression of VIP and VIP1-receptor in rat peritoneal lymphocytes and macrophages

https://doi.org/10.1016/0167-0115(96)00024-9Get rights and content

Abstract

In the present report we show the gene expression pattern of VIP and VIP1 receptor in two peritoneal cell populations, macrophages and lymphocytes by reverse transcription (RT) and polymerase chain reaction (PCR). Only in the lymphoid cells we have obtained a specific VIP cDNA product of 458 bp identical in size to the one obtained from cerebral cortex. On the other hand, we have obtained in both peritoneal populations lymphocytes and macrophages, a specific VIP1 receptor cDNA product of 311 bp identical in size to that obtained from lung. These results have been confirmed by Southern blot hybridization. Our findings suggest an autocrine/paracrine action of VIP in peritoneal microenvironment, supporting an immunoregulatory role for this neuropeptide.

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1Dr. Elvira Garrido died 5 March 1996 after a brief illness.

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