Original studyErythrocyte Na+, K+ pump inhibition after saline infusion in essentially hypertensive subjects: effects of canrenone administration
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Cited by (8)
Endogenous cardiotonic steroids in kidney failure: A review and an hypothesis
2015, Advances in Chronic Kidney DiseaseCitation Excerpt :One of the first clues that canrenone was a CTS receptor antagonist was the ability of therapeutic doses to reduce the effect of digitalis and ouabain on the heart.157-162 Subsequent work showed that canrenone suppressed ouabain binding to the Na+ pump61,163,164 and was antihypertensive in some experimental models of hypertension where ouabain-like factors were implicated.165-168 In therapeutically relevant concentrations, canrenone blocked the effect of ouabain on basal aortic tone77 and myogenic tone in pressured mesenteric arteries.169
Ouabain-inhibiting activity of aldosterone antagonists
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2021, Almanac of Clinical MedicineMarinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists
2015, Journal of HypertensionEndogenous cardiotonic steroids in chronic renal failure
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2009, Pharmacological Reviews
Copyright © 1989 Published by Elsevier Ireland Ltd.