Review
G protein regulation of receptor signalling

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Abstract

Binding of agonists to cell surface receptors provokes the release of a variety of intracellular second messenger molecules. There is now substantial evidence that the generation of these second messenger is controlled by a growing family of guanine nucleotide-binding (G) proteins, which couple the receptors to the second messenger-generating system. In this review Margaret Harnett and Gerry Klaus discuss the current evidence for G protein regulation of receptor signalling in cells involved in both innate and adaptive immune responses. Ridgeway, London NW7 1AA, UK.

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