B cell special
CD20: a regulator of cell-cycle progression of B lymphocytes☆

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Abstract

CD20 is a B-cell-specific cell-surface molecule with four membrane-spanning domains, as well as cytoplasmic N- and C-terminal domains. Here, Thomas Tedder and Pablo Engel discuss the suggestion that CD20 is a regulator of transmembrane Ca2+ onductance and plays an important functional role in B-cell activation, proliferation and differentiation.

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    ☆

    This work was supported by NIH grants AI-26872, CA-34183 and CA-54464. T.F.T. is a Scholar of the Leukemia Society of America.

    ∗

    The authors thank James Bubien and Kim Saunders for helpful discussions.

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