Trends in Genetics
Volume 7, Issue 10, October 1991, Pages 329-334
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HOX gene activation by retinoic acid

https://doi.org/10.1016/0168-9525(91)90423-NGet rights and content

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  • Cited by (200)

    • Opposing roles for the lncRNA haunt and its genomic locus in regulating HOXA gene activation during embryonic stem cell differentiation

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      Under this condition, Haunt transcripts were rapidly downregulated and HOXA genes remained silenced (Table S1), implying the need for a relevant biological context in which to assess Haunt function. RA is a well-characterized morphogen that regulates the spatial and temporal activation of HOX genes in vivo and in vitro (Boncinelli et al., 1991). Interestingly, the addition of RA not only activated HOXA genes but also enhanced the expression of Haunt (Figure 2A).

    • Retinoic acid receptors: From molecular mechanisms to cancer therapy

      2015, Molecular Aspects of Medicine
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      Thus, Ajuba also functions as a unique co-repressor for RAR/RXR (Hou et al., 2010). The HOX gene family is a large set of RA-regulated genes (Table 6) with a pivotal role in development and cell differentiation (Boncinelli et al., 1991; Langston and Gudas, 1994; Marshall et al., 1996). RAR binds to RAREs on HOX; subsequently the RA-induced transcriptional activation takes place (Dupé et al., 1997; Marshall et al., 1994; Thompson, 1997).

    • A high-throughput method for monitoring changes in homeobox gene expression

      2007, Biochemical and Biophysical Research Communications
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      Although Pitx1 and Pitx2 were strongly amplified by HD-256, many of the genes that were amplified by HD-128 were no longer amplified, or amplified at significantly reduced levels, by HD-256 even though the primer also had a 3′ A/G. Whether this indicates that a higher concentration of HD-256 is needed or that there is a limit to the amount of degeneracy that can be added to the primer mixture is unclear. This method is a non-quantitative assay designed for detecting large-scale changes in homeobox gene expression that are initiated by RA in stem cells such as the P19 and NT2/D1 lines [21]. It might also be sensitive enough to detect small-scale changes in expression, however.

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