Research reportMolecular characterization of a human brain adenosine A2 receptor
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2019, Food and Chemical ToxicologyCitation Excerpt :Response mediated by adenosine is associated with activation of specific cell-surface G-protein coupled receptors, which are classified into four subtypes: A1 receptor (A1R), A2AR, A2BR, and A3R (Fredholm et al., 1994). The first adenosine receptors cloned, A1R and A2AR, came from a library of orphan receptors from the dog thyroid (Libert et al., 1991; Maenhaut et al., 1990); and were also cloned from rat and human (Furlong et al., 1992; Mahan et al., 1991). A2BR was cloned from the rat brain (Stehle et al., 1992) whereas the fourth receptor, A3, was more unexpected (Zhou et al., 1992).
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