International Journal of Immunopharmacology
The detection of β-adrenoceptors on murine lymphocytes
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Autonomic regulation of T-lymphocytes: Implications in cardiovascular disease
2019, Pharmacological ResearchCitation Excerpt :A brief dive into the literature on the expression of ARs on T-lymphocytes will immediately appear contradictory. A number of studies have shown that T-lymphocytes exclusively express β2-AR [70–78]. However, this has been contradicted by other works as well, with reports of expression of β1-ARs, α1-ARs, and α2-ARs on T-lymphocytes.
Autonomic regulation of cellular immune function
2014, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The SNS-mediated-hemopoietic regulation may provide new targets for re-establish homeostatic maintenance of hematopoiesis under a number of conditions where βB-induced suppression of HPSC mobilization improves survival, like traumatic brain injury, burns, noncardiac surgery and trauma — conditions that strongly activate the SNS (Beiermeister et al., 2010). Sympathetically-mediated effects on thymocytes and thymic non-lymphoid cells (i.e., thymic epithelial, smooth muscle, and MCs) occur predominantly by catecholamine binding to β2- and α1-ARs (Loveland et al., 1981; Marchetti et al., 1994; Kavelaars, 2002; Pešić et al., 2009). Additionally, catecholamines can translocate to the nucleus where they influence transcription processes of steroid receptors and nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) to modulate apoptosis in thymocytes (Bergquist et al., 1997).
Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β <inf>1</inf> adrenoceptor
2012, Journal of NeuroimmunologyCitation Excerpt :ARs have been pharmacologically subdivided into nine AR subtypes through molecular cloning: three α1 subtypes (α1A, α1B, and α1D), three α2 subtypes (α2A, α2B, and α2C), and three β ARs (β1, β2, and β3) (Bylund et al., 1994; Civantos Calzada and Aleixandre de Artinano, 2001). Human peripheral blood and murine splenic T lymphocytes express β ARs, characterised mostly as the β2 AR subtype (Loveland et al., 1981; Van Tits et al., 1990). Recent reports indicated that β1and β3 ARs were also expressed in human peripheral blood T lymphocytes (Atanackovic et al., 2006), and α1B and α2C AR mRNA were expressed in rat mesenteric lymph nodes T lymphocytes (Bao et al., 2007).
Age-associated plasticity of α1-adrenoceptor-mediated tuning of T-cell development
2010, Experimental GerontologyCitation Excerpt :Moreover, it was suggested that, apart from NA of neural origin, thymic cellular NA, acting in both autocrine and paracrine ways, is involved in modulation of T-cell development (Pilipović et al., 2008). This role of NA is corroborated by the detection of β- and α1-adrenoceptors (ARs) on thymic lymphoid and non-lymphoid cells (Loveland et al., 1981; Marchetti et al., 1994; Kavelaars, 2002; Pešić et al., 2009). Furthermore, pharmacological studies implicated both subtypes of ARs in NA-mediated tonic inhibition of T-cell development (Plećaš-Solarović et al., 2004, 2005; Leposavić et al., 2006a; Pešić et al., 2009).
Catecholamines as immunomodulators: A role for adrenoceptor-mediated mechanisms in fine tuning of T-cell development
2008, Autonomic Neuroscience: Basic and ClinicalSympathetic modulation of immunity: Relevance to disease
2008, Cellular ImmunologyCitation Excerpt :Peptidergic and NA nerves form contacts with mast cells, ED1+ macrophages, and other lymphoid cells with varying frequency. Human and murine T lymphocytes express β2-AR [54,55,126–140]. T helper (Th)1 and Th2 cell clones generated from naïve cells differentially express β2-AR [141].