Peptide E and other proenkephalin-derived peptides are potent kappa opiate receptor agonists
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Cited by (67)
Isolation of new ligands for orphan receptor MRGPRX1—hemorphins LVV-H7 and VV-H7
2017, PeptidesCitation Excerpt :Thus, LVV-H7 and VV-H7 might be involved in pain perception via the MRGPRX1. Interestingly, the MRGPRX1 ligand BAM(1–22) is known to bind the opioid receptors (μ, δ and κ) and the binding can be blocked by the opioid receptor antagonist naloxone [6,11,30,35]. The activity of BAM(1–22) on opioid receptors is dependent on the opioid receptor binding motif, met-enkephalin, as BAM(8–22) does not activate the receptors [23].
Role of bovine adrenal medulla 22 (BAM22) in the pathogenesis of neuropathic pain in rats with spinal nerve ligation
2012, European Journal of PharmacologyCitation Excerpt :This peptide is widely distributed in the central nervous system in mammals (Khachaturian et al., 1983; Pittius et al., 1984) including superficial laminae of the spinal cord and small- as well as medium-sized neurons in DRG (Cai et al., 2007; Merchenthaler et al., 1986), the key structures involved in nociceptive processing (Millan, 1999). BAM22 possesses the classical opioid YGGFM motif (Boersma et al., 1994) and can activate μ- (Garzon et al., 1983), δ- (Lembo et al., 2002) and κ-opioid (Quirion and Weiss, 1983) receptors. Intriguingly, BAM22 is the only endogenous peptide that has been found to bind with high affinity to the human Mas oncogene-related gene (Mrg) receptors which are restricted to small-diameter DRG neurons in rodents and humans (Dong et al., 2001; Lembo et al., 2002).
Blockade of adrenomedullin receptors reverses morphine tolerance and its neurochemical mechanisms
2011, Behavioural Brain ResearchCitation Excerpt :The BAM22 peptide is a homogeny of leu- and met-enkephalins and has the classical opioid YGGFM motif. It can activate opioid receptors [10,33] in a naloxone-sensitive manner. Intracerebroventricular or i.t. administration of BAM22 inhibits urinary bladder reflex contractions [9], tail-flick reflex and formalin-induced nocifensive response [15] as well as spinal Fos expression [50] in a naloxone-reversed manner.
Sensory neuron-specific receptor agonist BAM8-22 inhibits the development and expression of tolerance to morphine in rats
2007, Behavioural Brain Research