ArticleTrophic influences of alpha-MSH and ACTH4–10 on neuronal outgrowth in vitro
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Transcribing the path to neurological recovery-From early signals through transcription factors to downstream effectors of successful regeneration
2011, Annals of AnatomyCitation Excerpt :It is possible, however, that the functionally important thing is not the up or down-change in cell body synthesis, but the fact that during regeneration, the peptide containing nerve terminals are not out in the peripheral tissues but in direct contact inside the self-restructuring nerve with neighbouring Schwann cells as well as other non-neuronal cells, permitting direct interactions. In vitro studies have also demonstrated that different neuropeptides – for example substance P, Somatostatin, Vasopressin, Calcitonin or alpha-MSH will exert a moderate though significant neurite outgrowth-promoting effect on central and peripheral neurons (Narumi and Fujita, 1978; Grimm-Jørgensen, 1987; Brinton and Gruener, 1987; Van der Neut et al., 1988). Studies using pharmacology and global deletion have recently confirmed such effects in vivo, for galanin, calcitonin gene-related peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Peptide (PACAP).
Brain effects of melanocortins
2009, Pharmacological ResearchNeuroprotective actions of melanocortins: a therapeutic opportunity
2008, Trends in NeurosciencesCitation Excerpt :Neurotrophic effects of melanocortins have long been recognized [49]. In initial studies, slices of fetal spinal cords in culture were used to test effects of α-MSH and ACTH (4–10) on the outgrowth of neurites from rat spinal neurons [50]. These experiments demonstrated that both peptides stimulated axonal outgrowth from fetal spinal cord slices in vitro.
Accelerating sensory recovery after sciatic nerve crush: Non-selective versus melanocortin MC<inf>4</inf> receptor-selective peptides
2004, European Journal of Pharmacology