ArticleSynthesis and biological evaluation of α-MSH analogues substituted with alanine
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Anterior Pituitary and Pars Intermedia Space
2020, Hormonal Signaling in Biology and Medicine: Comprehensive Modern EndocrinologyAnterior Pituitary and Pars Intermedia Space: Corticotrophs (ACTH) and Melanotrophs (α-MSH)
2019, Hormonal Signaling in Biology and Medicine: Comprehensive Modern EndocrinologyKey amino acid residue in Melanocortin-1 receptor (melanocyte α-MSH receptor) for ligand selectivity
2017, Molecular and Cellular EndocrinologyCitation Excerpt :Phe-Arg-Trp in MSH is identified to play an important role in ligand binding and signaling at MCRs (Yang et al., 2000; Haskell-Luevano et al., 1997b; Chen et al., 2006). When Phe, Arg and Trp in MSH were substituted with alanine, the ligand binding affinities and potencies were significantly decreased for these receptors (Grieco et al., 2002; Sahm et al., 1994; Bednarek et al., 1999). Substitution of Phe in position 7 of α-MSH with a DPhe (NDP-α-MSH) significantly increases ligand binding affinity and potency at MC1R, MC3R, MC4R and MC5R.
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016
2017, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :The full length peptide possesses nonselective sub-nanomolar to nanomolar potencies at the MC1R, MC3R, MC4R, and MC5R [46,47]. Alanine scans of α-MSH have also indicated the importance of the Met4, Phe7, Arg8, and Trp9 positions for binding and functional activity at the mouse MC1R and rat MC3R [48,49]. A 2016 report examining the cloned mouse receptors indicated that in addition to positions Met4, Phe7, Arg8, and Trp9, the Glu5 and His6 positions also affect functional activity [47].
A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist
2015, Bioorganic and Medicinal Chemistry LettersInteractions of the melanocortin-4 receptor with the peptide agonist NDP-MSH
2010, Journal of Molecular Biology
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Present address: Department of Pharmacy, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, BN2 4GJ, UK.