ArticleNeuromedin B stimulates arachidonic acid release, c-fos gene expression, and the growth of C6 glioma cells
References (32)
- et al.
Bombesin stimulates c-fos and c-jun mRNAs in small cell lung cancer cells
Peptides
(1995) - et al.
Molecular cloning of cDNAs encoding human bombesin-like peptide neuromedin B
J. Biol. Chem.
(1988) - et al.
Identification and characterization of neuromedin B receptors in the rat central nervous system
Methods Neurosci.
(1991) - et al.
Neuromedin B is a major bombesin-like peptide in rat brain: Regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord
Biochem. Biophys. Res. Commun.
(1984) - et al.
Neuromedin B-like peptide in rat brain: Biochemical characterization, mechanism of release and localization in synaptosomes
Peptides
(1986) - et al.
cDNA cloning, characterization and brain region-specific expression of a neuromedin-B preferring bombesin receptor
Neuron
(1991) - et al.
A substance P antagonist also inhibits specific binding and mitogenic effects of vasopressin and bombesin-related peptides in Swiss 3T3 cells
Biochem. Biophys. Res. Commun.
(1986) - et al.
The effect of arachidonic acid metabolites and lipoxygenase pathway inhibitors on in vitro growth of human lung cancer cell lines
- et al.
Molecular cloning of the bombesin/GRP receptor from Swiss 3T3 cells
- et al.
Bombesin: Potent effects on thermoregulation in rat
Science
(1977)
Bombesin affects the central nervous system to produce hyperglycemia in rats
Life Sci.
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Biochemistry
Basic methods in molecular biology
Bombesin supresses feeding in rats
Nature
A synthetic peptide that is a bombesin receptor antagonist
Nature
(Psi13,14)Bombesin analogues inhibit the growth of small cell lung cancer in vitro and in vivo
Cancer Res.
Cited by (19)
Effect of NMB-regulated ERK1/2 and p65 signaling pathway on proliferation and apoptosis of cervical cancer
2022, Pathology Research and PracticeCitation Excerpt :The overexpression of NMBR under hypoxic condition promotes breast cancer growth [10]. NMB is also associated with increased arachidonic acid and c-fos gene expression leading to the increased proliferation and poor prognosis in glioblastoma [11,12]. However, the role of NMB/NMBR in the progression of cervical cancer and its underlying mechanism are still unknown.
Neuromedin B regulates steroidogenesis, cell viability and apoptosis in rabbit Leydig cells
2020, General and Comparative EndocrinologyCitation Excerpt :We discovered that a certain dose of NMB could significantly activate PKC, but there was no significant change in PKA, that means PKC signaling pathway may be activated. Previous studies have shown that NMB binding to its receptor can activate PKC in some cellular responses, then leading to the expression of related genes, DNA synthesis and/or cellular effects (Lach et al., 1995; Moody et al., 1995; Rozengurt, 1998, 2007; Sancho et al., 2011; Weber, 2009). These results suggest that NMB may regulate the testosterone synthesis via NMBR/PKC/steroidogenesis signaling pathway, but the specific mechanism of the regulation of the steroidogenesis by NMB/NMBR system needs further study in male rabbit.
Bombesin receptors as potential targets for anticancer drug delivery and imaging
2019, International Journal of Biochemistry and Cell BiologyNeuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo
2011, Cancer LettersCitation Excerpt :Although the potential pathological role and regulatory mechanism of GRP in tumors has been a major focus of research [12–14], the function of NMB has received much less attention. Recently, there has been increasing evidence for the role of NMB in the growth and proliferation of malignant tumor cell lines [15–17]. We have previously shown that NMB acts as a direct proangiogenic factor of vascular endothelial cells [18].
Neuromedin B induces angiogenesis via activation of ERK and Akt in endothelial cells
2009, Experimental Cell ResearchNeuromedin B
2000, Progress in Neurobiology