Neuro-steroids: 3β-hydroxy-Δ5-derivatives in the rodent brain☆
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2021, Reproduction and BreedingKobayashi award: Discovery of cerebellar and pineal neurosteroids and their biological actions on the growth and survival of Purkinje cells during development (review)
2019, General and Comparative Endocrinology17β-Hydroxysteroid dehydrogenases and neurosteroid metabolism in the central nervous system
2019, Molecular and Cellular Endocrinology7α-Hydroxypregnenolone regulating locomotor behavior identified in the brain and pineal gland across vertebrates
2018, General and Comparative EndocrinologyAstrocytes as a target for neuroprotection: Modulation by progesterone and dehydroepiandrosterone
2016, Progress in NeurobiologyCitation Excerpt :However, the study by Corpéchot et al. (1981b) was important as it stimulated other researchers to investigate if the brain could be able to locally synthesize steroid hormones. Therefore, several studies confirmed the presence of steroidogenic enzymes in the brain of different species through different techniques (Robel and Baulieu, 1985; Le Goascogne et al., 1987; Mellon and Deschepper, 1993; Dupont et al., 1994; Mensah-Nyagan et al., 1994; Mathieu et al., 2001; Matsunaga et al., 2001). In the human brain, the areas with the highest expression of CYP11A1 are the olfactory bulb, thalamus, caudate nucleus, corpus callosum, hippocampus, hypothalamus, amygdala, cerebral cortex and cerebellum, while in rodents the cerebral cortex is the area with the highest expression of this enzyme (as reviewed by Pelletier, 2010).
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This refereed paper was presented during a special session on Neuroendocrinology—New Vistas, at the Collège de France, Paris, February–March 1984, organized by Dr A. Tixier-Vidal and Professor J. Glowinski, Drs H. Hamon, A. Tixier-Vidal and J. Glowinski acted as executive editors in the refereeing of this paper.