Noradrenaline and ATP as cotransmitters in sympathetic nerves
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Cited by (175)
Immunohistochemical localization of vesicular nucleotide transporter in small intensely fluorescent (SIF) cells of the rat superior cervical ganglion
2022, Tissue and CellCitation Excerpt :VNUT immunoreactivity in postganglionic neurons suggests that these neurons contain ATP-storing vesicles in addition to SIF cells. ATP is known to be co-released together with noradrenaline from postganglionic sympathetic neurons (Burnstock, 1990; Kennedy et al., 1996). In the rat carotid body, VNUT was immunohistochemically expressed in perivascular sympathetic nerve terminals derived from the superior cervical ganglion (Yokoyama et al., 2020).
The inevitability of ATP as a transmitter in the carotid body
2021, Autonomic Neuroscience: Basic and ClinicalPurinergic receptor antagonism: A viable strategy for the management of autonomic dysreflexia?
2021, Autonomic Neuroscience: Basic and ClinicalThe effects of varying Mg<sup>2+</sup> ion concentrations on contractions to the cotransmitters ATP and noradrenaline in the rat vas deferens
2019, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :With modern technology we can separate the cotransmitter-dependent contractions following a single electrical pulse into the 2 components of ATP and noradrenaline. This work cannot shed any light on the 3 hypotheses that 1) ATP and noradrenaline are co-stored in the one vesicle; 2) ATP and noradrenaline are stored in separate vesicles; or 3) that they are located in separate varicosities (Burnstock, 1990). The contraction to a single field pulse could be affected by Mg2+ acting at the release site on the sympathetic varicosity or on the post-junctional receptor and its smooth muscle effector machinery, or both sites.
Sympathetic innervation of the kidney in health and disease: Emphasis on the role of purinergic cotransmission
2017, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The release of ATP during stimulation of sympathetic nerves to the vas deferens was blocked by tetrodotoxin (showing that it was released from nerves), by guanethidine, an antagonist that acts by preventing release of sympathetic neurotransmitters and by 6-hydroxydopamine, that destroys sympathetic nerves. Sympathetic cotransmission to blood vessels was also shown (Burnstock, 1990, 1995; Katsuragi and Su, 1982; Sneddon and Burnstock, 1984b; see Fig. 5a and b). The currently accepted model of sympathetic cotransmission is shown in Fig. 6.