Decreased sympathetic innervation of spleen in aged fischer 344 rats☆
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Cited by (60)
The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia
2021, Ageing Research ReviewsCitation Excerpt :Noradrenergic networks are abundant in young adult rats, but in aged rats, noradrenergic innervation is less dense, and splenic NA levels are significantly lower. A relationship between diminished noradrenergic innervation and reduced immune responsiveness in aging mammals has been proposed (Felten et al., 1987). The mechanism by which organs lose sympathetic axon terminals is incompletely understood.
Neuroimmunology
2018, Comprehensive Toxicology: Third EditionNoni (Morinda citrifolia L.) fruit juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats
2017, Journal of EthnopharmacologyNeuroendocrine regulation of inflammation
2014, Seminars in ImmunologyAge-associated alterations in sympathetic noradrenergic innervation of primary and secondary lymphoid organs in female Fischer 344 rats
2011, Journal of NeuroimmunologyCitation Excerpt :Therefore, the restoration of thymopoiesis and reversal of thymic involution in aged rodents requires both the hematopoietic molecules and endocrine factors in order to abrogate immunosenescence. The age-associated reduction in sympathetic NA nerve density, and NE concentration and content, in the spleens of old female rats is consistent with the loss of sympathetic NA innervation observed in old male rats previously reported from our laboratory (Felten et al., 1987a, b; Bellinger et al., 1992; Bellinger et al., 2008; Perez et al., 2009), but occurs at an early age than reported for male rats (Table 1). The age-related decline in NE levels was approximately 60 to 70% in all the splenic compartments of old female rats, which is similar to that observed in old male rats (Felten et al., 1987a, b; Bellinger et al., 1992).
Quantifying perivascular sympathetic innervation: Regional differences in male C57BL/6 mice at 3 and 20 months
2009, Journal of Neuroscience Methods
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Supported by Grant N00014-84-K-0488 from the Office of Naval Research, 1 F32 NS07980-01 from NIMH (NINCDS), and by NIH Training Grant AG T32 107.