Elsevier

Toxicology

Volume 19, Issue 3, 1981, Pages 275-278
Toxicology

Short communication
The effect of 2,3-dimercaptopropane-1-sulfonate and dimercaptosuccinic acid on the distribution and excretion of mercuric chloride in rats

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Abstract

The effectiveness of 2,3-dimercaptopropane-1-sulfonate (DMPS) for the removal of mercuric chloride from the body of rats has been reported many times [e.g. 1–3]. Dimercapto succinic acid (DMSA) also appears to reduce the body burden of this mercurial [4,5]. Since DMSA is about 3 times less toxic than DMPS [6,7] a comparison of both chelants under identical conditions seemed interesting.

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Cited by (48)

  • Effect of DMPS and DMSA on the Placental and Fetal Disposition of Methylmercury

    2009, Placenta
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    The ability of mercuric ions to be extracted from placental and/or fetal tissues has not been examined thoroughly. Although it is well-established that the metal chelators, 2,3-dimercaptopropane-1-sulfonate (DMPS) and 2,3-dimercaptosuccinic acid (DMSA) can reduce the total body burden of CH3Hg+ [17–20], the ability of either chelator to extract mercuric ions from placental or fetal tissues has not been shown. Interestingly, administration of DMPS to pregnant mice exposed orally to CH3Hg+ appeared to protect fetuses from the toxic effects of methylmercury [21].

  • Molecular mechanisms triggered by mercury

    2008, Toxicology
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    In this way, even the local toxicity of the metal should be remarkably reduced (Nielsen and Andersen, 1991; Andersen and Molecular, 2002). Importantly, data from animal studies have shown that DMPS does not redistribute the mercury to the brain subsequent to the following exposure to mercury chloride (Planas-Bohne, 1981; Nielsen and Andersen, 1991; Aposhian et al., 1992). Despite the acknowledged mercury-mobilizing proprieties in various human clinical studies, DMPS administrated in mercury poisoned animal model has failed to remove the mercury from tissues (Aposhian et al., 2003).

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