Short communicationRenal metallothioein metabolism after a reduction of renal mass. I. Effect of unilateral nephrectomy and compensatory renal growth on basal and metal-induced renal metallothionein metabolism
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Mechanisms Involved in the Renal Handling and Toxicity of Mercury
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2017, Advanced Drug Delivery ReviewsCitation Excerpt :This strong affinity also contributes to the mechanism of toxicity where binding of mercuric ions to critical proteins can initiate cell injury pathways. Binding of mercuric ions to thiol-rich proteins, such as metallothionein, also increases intracellular retention [205–207]. The Cys-conjugated species of both inorganic and organic mercury seem to be the primary form found in proximal tubular cells.
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