Reflections on the kinetics of substrate binding

Dedicated to Professor Manfred Eigen on the occasion of his 60th birthday.
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Abstract

The principle questions which are still being asked about enzyme-substrate complex formation are examined. Data for the maximum rates of collision complex formation are reviewed. The limitations of past experimental procedures and the potentialities of new approaches are discussed together with methods that allow the distinction between collision complexes and subsequent events.

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    Present address (until 30 June 1987): Fogarty International Center, National Institutes of Health, Building 16, Room 309, Bethesda, MD 20892, U.S.A.

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