Elsevier

Neuroscience Letters

Volume 22, Issue 1, 23 February 1981, Pages 75-78
Neuroscience Letters

Histamine hyperpolarizes hippocampal neurones in vitro

https://doi.org/10.1016/0304-3940(81)90288-3Get rights and content

Abstract

The postsynaptic effect of histamine and impromidine, an H2-receptor agonist on CA1 pyramidal and dentate granule cells in the hippocampal slice of the rat is a hyperpolarization. Depolarizations are indirectly mediated. It is suggested that the hyperpolarization is generated by a conductance increase to potassium ions in the dendrites.

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