Elsevier

Neuroscience Letters

Volume 35, Issue 3, 14 March 1983, Pages 233-238
Neuroscience Letters

Evidence for interactions between [3H]glutamate and [3H]kainic acid binding sites in rat striatal membranes. Possible relevance for kainic acid neurotoxicity

https://doi.org/10.1016/0304-3940(83)90323-3Get rights and content

Abstract

In vitro studies have shown that kainic acid (10−6 M) but not N-methyl-d-aspartate (NMDA) in the same concentration reduces the number of striatal [3H]glutamate binding sites and increases their affinity in striatal membranes. In vitro studies also show that l-glutamate (10−8 M) but not NMDA (10−6 M) increases the number of [3H]kainic acid binding sites and reduces their affinity in striatal membranes. Ibotenic acid (10−6 M) can also reduce the affinity of [3H]kainic acid binding sites in striatal membranes. These results give indications for the existence of bidirectional receptor-receptor interactions between two receptors for excitatory amino acids in local striatal circuits. These interactions could partly explain the involvement of glutamate in kainate neurotoxicity.

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