Elsevier

Neuroscience Letters

Volume 35, Issue 1, 31 January 1983, Pages 41-45
Neuroscience Letters

Receptor for ATP in the membrane of mammalian sensory neurones

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Abstract

ATP-activated conductance has been found in a large number of neurones isolated from various sensory ganglia of the rat and cat. The inward current produced by ATP (Kd = 5 · 10−6 M) is carried by cations and demonstrates rapid activation and slow desensitization. The sequence of agonists (ATP > ADP) with AMP and adenosine ineffective) is different from those previously described for purinergic receptors P1 and P2.

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